PDF下载 ( 2289 KB)
肝窦内皮细胞与肝纤维化的关系
DOI: 10.3969/j.issn.1001-5256.2023.02.027
利益冲突声明：所有作者均声明不存在利益冲突。
作者贡献声明：戴伟明负责文章结构设计，撰写文章；陆伦根负责论文修改；蔡晓波负责拟定写作思路，修改文章。
Association between liver sinusoidal endothelial cells and liver fibrosis
-
摘要: 生理情况下，肝窦内皮细胞(LSEC)对肝脏稳态的维持起重要作用。而在肝脏病理损伤条件下，LSEC可通过改变其自身结构即毛细血管化对损伤做出反应，并加重肝损伤。此外，LSEC与肝脏中其他细胞的相互作用对肝纤维化的发生发展也有一定作用，其中与肝纤维化的主要效应细胞——肝星状细胞的交互作用占主体地位。本文主要阐述慢性肝损伤时LSEC在肝纤维化发生发展中的作用。
-
关键词:
- 肝硬化 /
- 肝窦内皮细胞 /
- 肝星状细胞
Abstract: Liver sinusoidal endothelial cells (LSECs) are crucial to the maintenance of hepatic homeostasis under physiologic conditions, while under the conditions of pathological liver damage, LSEC can respond to the damage by changing their structure through the process called capillarization, thereby aggravating liver damage. In addition, the interaction between LSEC and other cells in the liver plays a certain role in the development and progression of liver fibrosis, especially the interaction between LSEC and hepatic stellate cells, which are the primary effector cells of liver fibrosis. This article mainly elaborates on the role of LSEC in the development and progression of liver fibrosis during chronic liver injury.-
Key words:
- Liver Cirrhosis /
- Liver Sinusoidal Endothelial Cells /
- Hepatic Stellate Cells
-
图 1 正常或毛细血管化肝窦内皮细胞对肝纤维化的影响
Figure 1. Effect of normal or capillarized liver sinusoidal endothelial cells on liver fibrosis
下载:
全尺寸图片
幻灯片
相关内容推荐
孙智君李志深柏林裤顾冠群铁拳4牛郎织女的手抄报我的梦英文版原唱苏州卓美百货商场拉斯科紫灰山隐蛇蜘蛛岛李明月魔兽世界t10美女的心跳声罗技鼠标保修几年窃夫杜燕敖子龙罗鑫特雷姆斯人气王jacd红警之坦克风暴索尼娅内瓦曼雀友麻将机档位表燕字怎么写好看踩踩踩健美操侯希贵胡月兰人体不知天上宫阙读音we怎么写章晓周湘甫以该杂诗雷鸣球缅甸仰光安全吗胡泽平逸卡一虎血仆是什么意思水兵舞第二套大疆电池循环次数cf道具城江言振风塔思明区政府强哥烧烤护生咒余昭都教授说房琅琊区政府张硕文家乐芬美女天天看贝汯璘关静山劲爆美女医职园李星宇薛珊珊老朋友进行曲江夏佑黑天鹅湖梅林水库恶魔妹妹火箭摩托车谭建勋猫毛草的图片模特春晓udg奥奇传说辅助葛玄常威在打来福我爱你手语罗休休山城棒棒军主题曲steamapp全民老公白龙池黄山鲫鱼背梦郭嘉扒蒜小妹孟子坤个人资料李怀义涩漫画冬荷葡萄树歌曲儿歌程德伟美蕾清水丽子3ds恶魔城虾辣许嘉文广州第二CBD王清泉海潮之石阿米娜奥库维娃小猪舞双龙桥许霞果冻宝贝荒野乱斗新英雄奔驰女aiya梨花坞韩松日本留学现状中国最年轻的博士奥运会礼仪小姐河南哪个县最穷乔帮主敖日格勒宏程序乌日根军少霸爱只做不婚朗诵滕王阁序肚肚小平头敖汉拨面张阳阳be电影咖啡机车韩国主播bj奇米7抖音商品橱窗国色天香视频金美子赛尔号年费征途08版樊斌三和红姐普瑞思顿香港最高楼白玉花吴思科pa18唐河乡真龙甲天下叮咚淘以撒的结合代码角徵高美丽火车模型视频商洛gdp僵尸视频胡扬林33000日元陈冠希的店小草歌曲原唱卅六鸳鸯馆皮揣子钱难挣的顺口溜雪碧视频上海磁悬浮多少钱刘成斋桃江地震洛文崽湖北书记宋谷金少刚李贞贤扇子舞简单易学的舞蹈依依妖妖色怕怕陌南尘是非功过任评说挖土机视频金一明英雄儿女主题曲西安后海在哪里陈秋良世界第一打野校园吻戏十字跳sonyn50张保全火柴人2泰国电影院七彩阳光镜面银泰几点开门皮揣子李秋香李昃佑振风塔贝湖鱼3d韩漫相思门最简单的广场舞陈章树叠字草书长条气球造型教程蕾蕾少涵攻暗恋受怎么调戏女朋友广顺兴猪肚鸡刘小小济南轻轨二手哈飞路宝奶牛视频欧美黑白配
合作伙伴
www.akz.net.cn
www.clhczx.cn
www.haowangjiao.cc
www.kapauw.com
www.desai360.com
seo.chaoshanxing.com
seo.jsfengchao.com
niu.seo5951.com
www.youpinhui.vip
www.7272w.cn
www.8830000.cn
www.weiwin.cc
www.tjwyj.com
jl.urkeji.com
www.ddtxly.cn
seo.chaoshanxing.com
zz.urkeji.com
www.maijichuang.cn
www.te3.com.cn
baidu.07yue.com
-
[1] LI H. Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma[J]. Dig Liver Dis, 2022, 54(5): 598-613. DOI: 10.1016/j.dld.2021.07.006. [2] DELEVE LD, WANG X, HU L, et al. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation[J]. Am J Physiol Gastrointest Liver Physiol, 2004, 287(4): G757-G763. DOI: 10.1152/ajpgi.00017.2004. [3] POISSON J, LEMOINNE S, BOULANGER C, et al. Liver sinusoidal endothelial cells: Physiology and role in liver diseases[J]. J Hepatol, 2017, 66(1): 212-227. DOI: 10.1016/j.jhep.2016.07.009. [4] SUN X, HARRIS EN. New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease[J]. Am J Physiol Cell Physiol, 2020, 318(6): C1200-C1213. DOI: 10.1152/ajpcell.00062.2020. [5] ZAPOTOCZNY B, SZAFRANSKA K, KUS E, et al. Tracking fenestrae dynamics in live murine liver sinusoidal endothelial cells[J]. Hepatology, 2019, 69(2): 876-888. DOI: 10.1002/hep.30232. [6] XIE G, WANG L, WANG X, et al. Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity[J]. Am J Physiol Gastrointest Liver Physiol, 2010, 299(5): G1204-G1210. DOI: 10.1152/ajpgi.00302.2010. [7] DELEVE LD. Liver sinusoidal endothelial cells in hepatic fibrosis[J]. Hepatology, 2015, 61(5): 1740-1746. DOI: 10.1002/hep.27376. [8] SIMON-SANTAMARIA J, RINALDO CH, KARDAS P, et al. Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta[J]. PLoS One, 2014, 9(11): e111762. DOI: 10.1371/journal.pone.0111762. [9] BHANDARI S, LARSEN AK, MCCOURT P, et al. The scavenger function of liver sinusoidal endothelial cells in health and disease[J]. Front Physiol, 2021, 12: 757469. DOI: 10.3389/fphys.2021.757469. [10] LI TP, GUAN SH, WANG Q, et al. Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure[J]. World J Gastroenterol, 2019, 25(37): 5667-5675. DOI: 10.3748/wjg.v25.i37.5667. [11] TURMAN JM, CHEPLOWITZ AM, TIWARI C, et al. Accelerated clearance and degradation of cell-free HIV by neutralizing antibodies occurs via FcγRⅡb on liver sinusoidal endothelial cells by endocytosis[J]. J Immunol, 2021, 206(6): 1284-1296. DOI: 10.4049/jimmunol.2000772. [12] HAMMOUTENE A, RAUTOU PE. Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease[J]. J Hepatol, 2019, 70(6): 1278-1291. DOI: 10.1016/j.jhep.2019.02.012. [13] LAFOZ E, RUART M, ANTON A, et al. The endothelium as a driver of liver fibrosis and regeneration[J]. Cells, 2020, 9(4). DOI: 10.3390/cells9040929. [14] MCGUIRE RF, BISSELL DM, BOYLES J, et al. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver[J]. Hepatology, 1992, 15(6): 989-997. DOI: 10.1002/hep.1840150603. [15] MOHAMAD M, MITCHELL SJ, WU LE, et al. Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance[J]. Aging Cell, 2016, 15(4): 706-715. DOI: 10.1111/acel.12481. [16] DI MARTINO J, MASCALCHI P, LEGROS P, et al. Actin depolymerization in dedifferentiated liver sinusoidal endothelial cells promotes fenestrae re-formation[J]. Hepatol Commun, 2019, 3(2): 213-219. DOI: 10.1002/hep4.1301. [17] GRACIA-SANCHO J, CAPARRÓS E, FERNÁNDEZ-IGLESIAS A, et al. Role of liver sinusoidal endothelial cells in liver diseases[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(6): 411-431. DOI: 10.1038/s41575-020-00411-3. [18] MAK KM, KEE D, SHIN DW. Alcohol-associated capillarization of sinusoids: A critique since the discovery by Schaffner and Popper in 1963[J]. Anat Rec (Hoboken), 2022, 305(7): 1592-1610. DOI: 10.1002/ar.24829. [19] DU W, WANG L. The crosstalk between liver sinusoidal endothelial cells and hepatic microenvironment in nash related liver fibrosis[J]. Front Immunol, 2022, 13: 936196. DOI: 10.3389/fimmu.2022.936196. [20] DELEVE LD, WANG X, GUO Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence[J]. Hepatology, 2008, 48(3): 920-930. DOI: 10.1002/hep.22351. [21] JARNAGIN WR, ROCKEY DC, KOTELIANSKY VE, et al. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EⅢA segment in rat hepatic fibrogenesis[J]. J Cell Biol, 1994, 127(6 Pt 2): 2037-2048. DOI: 10.1083/jcb.127.6.2037. [22] MARRONE G, RUSSO L, ROSADO E, et al. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins[J]. J Hepatol, 2013, 58(1): 98-103. DOI: 10.1016/j.jhep.2012.08.026. [23] LEMOINNE S, CADORET A, RAUTOU PE, et al. Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles[J]. Hepatology, 2015, 61(3): 1041-1055. DOI: 10.1002/hep.27318. [24] DESROCHES-CASTAN A, TILLET E, RICARD N, et al. Bone morphogenetic protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis[J]. Hepatology, 2019, 70(4): 1392-1408. DOI: 10.1002/hep.30655. [25] TATEYA S, RIZZO NO, HANDA P, et al. Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding[J]. Diabetes, 2011, 60(11): 2792-2801. DOI: 10.2337/db11-0255. [26] ROH YS, SEKI E. Chemokines and chemokine receptors in the development of NAFLD[J]. Adv Exp Med Biol, 2018, 1061: 45-53. DOI: 10.1007/978-981-10-8684-7_4. [27] YANG Y, SANGWUNG P, KONDO R, et al. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease[J]. J Hepatol, 2021, 75(2): 377-386. DOI: 10.1016/j.jhep.2021.02.028. [28] FANG ZQ, RUAN B, LIU JJ, et al. Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase[J]. Hepatology, 2022, 76(3): 742-758. DOI: 10.1002/hep.32332. [29] CHEN L, GU T, LI B, et al. Delta-like ligand 4/DLL4 regulates the capillarization of liver sinusoidal endothelial cell and liver fibrogenesis[J]. Biochim Biophys Acta Mol Cell Res, 2019, 1866(10): 1663-1675. DOI: 10.1016/j.bbamcr.2019.06.011. [30] RUART M, CHAVARRIA L, CAMPRECIÓS G, et al. Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury[J]. J Hepatol, 2019, 70(3): 458-469. DOI: 10.1016/j.jhep.2018.10.015. [31] WINKLER M, STANICZEK T, KVRSCHNER SW, et al. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling[J]. J Hepatol, 2021, 74(2): 380-393. DOI: 10.1016/j.jhep.2020.08.033. [32] WU X, SHU L, ZHANG Z, et al. Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells[J]. Adv Sci (Weinh), 2021, 8(11): e2003721. DOI: 10.1002/advs.202003721. [33] WU Y, LI Z, XIU AY, et al. Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice[J]. Drug Des Devel Ther, 2019, 13: 2667-2676. DOI: 10.2147/DDDT.S210797. [34] ABRALDES JG, RODRÍGUEZ-VILARRUPLA A, GRAUPERA M, et al. Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats[J]. J Hepatol, 2007, 46(6): 1040-1046. DOI: 10.1016/j.jhep.2007.01.020. [35] MARRONE G, MAESO-DÍAZ R, GARCÍA-CARDENA G, et al. KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins[J]. Gut, 2015, 64(9): 1434-1443. DOI: 10.1136/gutjnl-2014-308338. [36] BRAVO M, RAURELL I, HIDE D, et al. Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH[J]. Sci Rep, 2019, 9(1): 20183. DOI: 10.1038/s41598-019-56366-2. [37] HU L, SU L, DONG Z, et al. AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model[J]. J Mol Med (Berl), 2019, 97(3): 423-434. DOI: 10.1007/s00109-019-01746-4. [38] HUNT NJ, LOCKWOOD GP, KANG S, et al. The effects of metformin on age-related changes in the liver sinusoidal endothelial cell[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(2): 278-285. DOI: 10.1093/gerona/glz153. [39] TALAMINI L, PICCHETTI P, FERREIRA LM, et al. Organosilica cages target hepatic sinusoidal endothelial cells avoiding macrophage filtering[J]. ACS Nano, 2021, 15(6): 9701-9716. DOI: 10.1021/acsnano.1c00316. [40] BAE CR, ZHANG H, KWON YG. The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice[J]. PLoS One, 2020, 15(12): e0243497. DOI: 10.1371/journal.pone.0243497. -
摘要
HTML全文
参考文献(40)
相关文章
施引文献
资源附件(0)
本文二维码
图(1)
计量
- 文章访问数: 1117
- HTML全文浏览量: 741
- PDF下载量: 122
- 被引次数: 0
